Technical Review

モノリス型シリカカラムの調製と性能評価
Preparation and Evaluation of Monolithic Silica Columns for HPLC

宮崎将太¹、太田茂徳¹、森里恵¹²、中西和樹²、大平真義¹、田中信男¹³
Shota Miyazaki¹, Shigenori Ota¹, Kei Morisato^1,2, Kazuki Nakanishi², Masayoshi Ohira¹, Nobuo Tanaka^1,3

¹GL Sciences Inc., 237-2 Sayamagahara, Iruma, Saitama, 358-0032, Japan
²Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
³Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan

Abstract:

Monolithic silica columns have been developed to provide the performance beyond the limit of conventional particulate columns along with the columns packed with sub.2 μm particles or core.shell particles. This review describes (1) the preparation method of monolithic silica gel, (2) the surface modification method, (3) the method of column fabrication, and (4) the evaluation method of column performance.

Keywords: monolithic silica column, silica preparation, surface modification, column fabrication, column evaluation

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