CHROMATOGRAPHY, Vol. 33 (2012), No. 2, pp. 97-105
Technical Review
The basics of gas chromatography tandemmass spectrometry (GC/MS/MS) and application for selective and quantitative analysis of environmental samples
Takashi Kasamatsu
Agilent Technologies Japan, Ltd., Application Center
4-16-36 Shibaura, Minato-ku, Tokyo 108-0023, Japan
In the analysis by gas chromatography mass spectrometry (GC/MS), the demand of high selectivity and high sensitivity is becoming severe. However, in analysis of polychlorinated biphenyl (PCB) and odorant in drinking water, interference by internal standard may occur, and in analysis of pesticides, interference by other analytes and unwanted substances from sample may occur at low concentration. In such cases, analysis may be difficult by selected ion monitoring (SIM) of GC/MS, but analysis by gas chromatography tandem mass spectrometry (GC/MS/MS) is effective. In this paper, the basic theory, effect and its example of application of GC/MS/MS are explained.
Keywords: gas chromatography mass spectrometry (GC/MS), gas chromatography tandem mass spectrometry (GC/MS/MS), high selectivity, high sensitivity.