CHROMATOGRAPHY, Vol. 32 (2011), No. 3, pp. -161

福島景子、橋口九州男、鈴木隆弘、大河原正光、関口陽子
Kyoko Fukushima, Kusuo Hashiguchi, Takahiro Suzuki, Masamitsu Okawara and Yoko Sekiguchi

Corona Charged Aerosol Detector (CAD) has become standard for many applications in a variety of industries. The Corona is a mass sensitive universal detector for non-volatile and some semi-volatile analytes and response is independent of chemical structure, unlike absorbance, fluorescence, or electrochemical detectors. CAD is an evaporative technique and is based on the charging of aerosol-borne analyte particles by nitrogen gas and corona discharge, with subsequent measurement of the charged analyte particles by a high sensitivity electrometer.
The next-generation Corona ultra detector which supported super-high-speed liquid chromatography (UHPLC) in 2009 was developed. This detector can effectively analyze a wide diversity of chemical structures and important classes of molecules.