Original

いわゆる「ホスピタルダイエット」類似製品におけるGC-MS法及びLC-MS-MS法を用いた含有医薬品成分の分析
Analysis of Undeclared Pharmaceutical Ingredients Found in a Dietary Supplement-Type Product for Weight Loss, So-Called "Hospital Diet", Using GC-MS and LC-MS MS methods

Kenichi KUMASAKA^＊, Maki MIYAZAWA, Ayako MATSUZAKA, Yoriko ASO and Takashi KOJIMA

Kanagawa Prefecturel Institute of Public Health, 1-3-1 Shimomachiya, Chigasaki, Kanagawa 253-0087, Japan

Abstract:

We investigated the undeclared pharmaceutical ingredients in a dietary supplement-type product, composed of six types of tablets and two types of capsules. The appearance of this product was closely similar to that of the so-called “hospital diet” that was marketed on the internet and advertised for weight loss. Thus, appearances and imprints of the samples were used to determine the pharmaceutical ingredients in the tablets and capsules because warnings, photographs, and health risks of similar products were shown on the website of the Japanese Ministry of Health, Labor and Welfare. In fact, a histological study revealed that thyroid gland powder was contained in two types of the tablets. In addition, GC-MS and Qtrap LC-MS-MS methods revealed the presence of thyroid hormones and the following five pharmaceutical ingredients: bisacodyl, hydrochlorothiazide, fluoxetine, diazepam and phentermine.

Keywords: hospital diet, weight loss, undeclared pharmaceutical ingredients, GC-MS, Qtrap LC-MS-MS

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