CHROMATOGRAPHY, Vol. 22 (2001), No. 3, pp. 159-170

Enantiomeric Separation by CEC Using Chiral Stationary Phases
Masaru Kato* and Toshimasa Toyo'oka
University of Shizuoka, School of Pharmaceutical Sciences 52-1, Yada, Shizuoka, Shizuoka, 422-8526, Japan

Capillary electrochromatography (CEC) is now a promising technique for enantiomeric separation, because of the high separation efficiency of the technique. In the last few years, many chiral stationary phases (CSPs) were prepared for CEC and acidic, neutral, and basic enantiomers were separated by these CSPs. These CSPs are classified into three types : (I) open tubular capillary, (II) packed capillary and (III) monolithic capillary. In this review, we evaluate these types of CSPs and compared separation conditions (inner diameter of capillary and mobile phase) and data (theoretical plate number, separation factor and resolution) by these CSPs.
Keywords: capillary electrochromatography, enantiomeric separation, chiral stationary phase

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