|
Focussing Review
New organic phase for biomimetic HPLC
Enhanced molecular-shape selectivity through molecular orientation |
| Hirotaka Ihara |
Graduate School of Science & Technology, Kumamoto University
Kumamoto 860-8555, Japan |
Abstract:
Lipid membranes work as important media for generation of various biofunctions in which precise separation and permeation of chemical substances are included. Therefore, immobilization of lipid membrane functions onto carrier particles such as silica promises to increase possible applications, especially in column separation chemistry. However, stabilization of lipid membranes is generally accompanied by disappearance of lipid membrane functions because of suppressing the lateral diffusion of lipids. To overcome this dilemma, we have developed a method to graft the comb-shaped polymers as lipid membrane analogues. In this review, we wish to introduce that specific separation behavior in HPLC can be realized through highly-oriented structures from the lipid membrane analogues on silica.
|
| Keywords: | liquid chromatography, molecular recognition, shape selectivity, highly-oriented structure, carbonyl-p interaction, thermo-responsible polymer, lipid bilayer membranes |
|
|
|
