CHROMATOGRAPHY, Vol. 32 (2011), No. 2, pp. -95

Silicone polymer-coated packing materials were developed by coating silica with a silicone polymer, and modifying it with vinyl compounds in the presence of hexachloroplatinic acid. This silicone polymer coating, which indicates that the homogeneous silicone polymer film of 7Å in thickness was formed and that it was formed even inside the small micropore. This silicone polymer-coated silicas showed both a high resolution of chemically bonded silicas and an alkaline resistance of organic porous polymer. Polymer-coated C18 packings optimized in the balance of polymer coating and introduction of C18 groups showed a high symmetrical peak shape for amitriptyline, a strong basic compound, under neutral conditions obtained in different organic modifiers, methanol and acetonitrile. The silicone polymer-coated packing materials showed a good reproducibility in the comparison with conventional chemically bonded silicas of different surface activity.