CHROMATOGRAPHY
CHROMATOGRAPHY, Vol. 25 (2004), No. 1, pp. 9-23
Focussing Review
Development of Chiral Separation Systems for Capillary Electrophoresis, Electrochromatography and Liquid Chromatography
Zilin Chen
NTT Microsystem Integration Laboratories, 3-1 Morinosato Wakamiya, Atsugi, Kanagawa 243-0198, Japan
Abstract:
This review paper summarizes the authorfs research work on the development of chiral separation systems undertaken since 1997 during which time he has studied and worked at Tokyo Metropolitan University. The main topics include ligand.exchange capillary electrophoresis, ligand.exchange micellar electrokinetic chromatography, chiral monolithic silica columns and their applications in chiral capillary electrochromatography and microcolumn.liquid chromatography, electrokinetic capillary chromatography using 18.crown.6 tetracarboxylic acid as a chiral selector and/or using the surfactant of sodium alkyl polyoxyethylene sulfate as a pseudo.stationary phase in the electrolyte, and the diamide.type chiral stationary phase for liquid chromatography.
Keywords: Chiral separation; Chiral stationary phase; Ligand exchange; Monolithic column; Capillary electrochromatography; Capillary electrophoresis; Micro.liquid chromatography; Micellar electrokinetic chromatography; Amino acid; Hydroxy acid; Amino acylamide; Cyclodextrin.